Pilot Plants
Our two main production units are manually controlled, overpressured multi-purpose units.
Each reactor is independently ventilated to avoid cross-contamination; the Hastelloy C reactor is particularly useful for running organometallic chemistry – typically lithiations, Grignards or hydride reductions.
Unit 1
- 250L, 500L and 1600L gl reactors
- 1000L crystallisation reactor
- 1,000 mm ss centrifuge (Class 100,000 HEPA environment)
- Operating parameters: -15 to 140 °C (internal temp)
- Overpressured and filtered air supply; airlocked
- Vacuum tray drier (Class 100,000 HEPA environment) – (capacity up to 50 kg)
- 20L ss mobile drum blender
- 0.6m2 QVF glass thin film evaporator
Unit 2
- 1000L Hastelloy C reactor with glass and gl overheads (operable down to -80°C)
- 100L ss hydrogenation reactor (10 bar)
- 600mm PFA coated centrifuge
- 35L Hastelloy C reactor (operable down to -80°C)
- 20L Glass-top Distillation reactor
- 20L gl reactor with DN100 distillation column
- Huber thermostat (-80 to 200°C)
When scaling up, we recognise the need to eliminate reactions at cryogenic temperatures wherever possible in order to reduce costs, but we also know that this is not always achievable – some chemistry simply won’t work at elevated temperatures.
For more information visit cGMP API Manufacture.
