At SONEAS Research we have experience in a wide variety of chemistries,
with particular expertise in heterocyclic and organometallic chemistry. We made many nitrogen-containing heterocycles including

 

  • Quinolines
  • Isoquinolines
  • Pyridines
  • Pyrimidines
  • Indazoles
  • Carbazoles

 

along with more elaborate bicyclic and polyheterocyclic ring systems such as

 

  • Thienopyridines
  • Thienopyrimidines
  • Azaindoles
  • Benzofuropyrimidines

 

With facilities to undertake cryogenic reactions at up to 1,000 litre scale we routinely handle

 

  • Grignard reagents
  • Organozinc reagents
  • Hexyl lithium
  • Metal hydrides

 

We also have much experience in metal-mediated coupling reactions

 

  • Suzuki
  • Sonagashira
  • Heck

 

and solving problems in relation to removal of residual metals.

Synthesis and manufacture of materials without a UV-chromophore is also an area where we have expertise.

In such cases, for example sugar analogues, or compounds with long lipophilic chains, we utilise Corona CAD HPLC detectors to determine purity. Our skilled, trained chemists and plant operators enable us to work safely with reagents requiring special care such as the following…

 

  • Triphosgene
  • Cyanation – Na/KCN
  • OsO4 – cis dihydroxylation
  • Hydrazine chemistry
  • Sodium azide chemistry – Curtius chemistry, amine formation
  • Alkylations using MeI, dimethyl/diethyl sulphate
  • Ethylene oxide
  • Peroxides
  • Cyclopentadiene chemistry

 

SONEAS Chemicals, our commercial scale production site provides:

 

  • Optical resolutions
  • High temperature reactions
  • Hydrogenations
  • Acid chloride preparations
  • Carbene additions
  • Diazotizations
  • Friedel-Crafts reactions and isomerizations
  • Cyanations
  • Cyclopropanation
  • Cyclopentadiene chemistry
  • Diazoacetate reactions
  • Oxidations
  • Reductions
  • Halogenations

 

A lot of the chemistry we undertake is under confidentiality agreements, so we can’t discuss it more widely, but in some cases our chemists are named on clients’ patents, and we would be happy to provide details on request.

 

Why not put us to the test and see how we can add value and expertise to your development projects…

 

Chemistries

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